3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin
| Post Date: |
Dec 07,2018 |
| Expiry Date: |
Dec 07,2019 |
| Detailed Description: |
Cas No. :26638-53-9
3-Chloro-6-methyl-dibenzo [c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide,a key intermediate of Tianeptine,was synthesized from 4-chloro-2-sulfonylchloride methyl benzoate via condensation,methylation,hydrogenolysis and cyclization in an overal yield of 55.9%.The influences of acid-capturer pyridine dosage on condensation and sodium hydride dosage on hydrogenolysis were optimized as follows:n(4-chloro-2-sulfonylchloride methyl benzoate):n(pyridine)=1:1.86,n(4-chloro-2-(N-methyl-N-phenylsulphonamide)methyl benzoate):n(sodium hydride)= 1:3.The optimal temperature for cyclization reaction was obtained to be 100～110℃.IR,1H NMR and MS were used for structure identification. |
| CAS Registry Number: |
|
| Synonyms: |
;3-Chloro-6-methyl-S,S-dioxyde-dibenzo[c,f]thiazepin-11(6H)-one;3-chloro-6,11-dihydro-5,5,11-trioxo-6-methyldibenzo[c,f][1,2]thiazepine; |
| Molecular Formula: |
C14H10ClNO3S |
| Molecular Weight: |
307.7521 |
| Molecular Structure: |
![26638-53-9 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide](https://images.chemnet.com/suppliers/chembase/cas/cas26638-53-9.gif)
|
| Company: |
Jinan Chenghishaungda Chemical Co.,LTD
[ China ]
|
| Contact: |
Allen |
| Tel: |
15689693073 |
| Fax: |
0531-58897032 |
| Email: |
3118607598@qq.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
